Simple, stereocontrolled syntheses of 24(S),25-epoxy-22(R)-hydroxycholesterol, 22(R),24(S)-dihydroxycholesterol and diastereomers, new ligands for binding and activation of LXRs

✍ Scribed by E.J. Corey; Michael J. Grogan

• Book ID: 104260315
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 119 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)02182-0

✦ Synopsis

Described herein are stereocontrolled syntheses of a series of sidechain oxygenated cholesterols for the study of binding and activation of nuclear receptors of the LXR family.