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ChemInform Abstract: Stereocontrolled Syntheses of 24(S),25-Epoxycholesterol and Related Oxysterols for Studies on the Activation of LXR Receptors.

✍ Scribed by E. J. Corey; Michael J. Grogan

Publisher: John Wiley and Sons
Year: 2010
Weight: 37 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199910196

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✦ Synopsis

Stereocontrolled Syntheses of 24(S),25-Epoxycholesterol and Related Oxysterols for Studies on the Activation of LXR Receptors. -The title epoxide (IV) and derivatives thereof such as (V) and (VII) are prepared as interesting ligands and functional activators of LXR receptors. It is noteworthy that (VII) is the first known selective activator of LXRα vs. LXRβ. -(COREY, E.

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