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Statistical methods for analysis of high-throughput RNA interference screens

✍ Scribed by Birmingham, Amanda; Selfors, Laura M; Forster, Thorsten; Wrobel, David; Kennedy, Caleb J; Shanks, Emma; Santoyo-Lopez, Javier; Dunican, Dara J; Long, Aideen; Kelleher, Dermot

Book ID
109935428
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
395 KB
Volume
6
Category
Article
ISSN
1552-4450

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About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled s