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A Method for High-Throughput Screening of Enantioselective Catalysts

✍ Scribed by Manfred T. Reetz; Michael H. Becker; Heinz-Werner Klein; Detlef Stöckigt

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
119 KB
Volume
38
Category
Article
ISSN
0044-8249

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✦ Synopsis

About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled substrates. The picture shows the mass spectrum of the mixture obtained upon hydrolysis of 1 to afford the pseudo-enantiomeric products 2 and 3.

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A Practical NMR-Based High-Throughput As
A Practical NMR-Based High-Throughput Assay for Screening Enantioselective Catalysts and Biocatalysts
✍ Manfred T. Reetz; Andreas Eipper; Patrick Tielmann; Richard Mynott 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB 👁 2 views

Two NMR-based approaches for highthroughput screening of enantioselective catalysts and biocatalysts are described. One version makes use of pseudo-enantiomers or pseudo-meso-compounds based on 13 C-labeling. A throughput of at least 1400 ee determinations per day is possible by using an appropriate