In the biosynthesis of labeled S-adenosylmethionine and S-adenosylethionine from the corresponding 1"-labeled sulfur amino acids by yeast, some radioimpurity occurred by non-speci@ labeling of the sulfonium compounds. This is explained by partial degradation of methionine and ethionine in the yeast
Stable Organophosphorus Analogues of S-Adenosylmethionine and S-Methylmethionine.
β Scribed by Kirill V. Alferov; Yurii N. Zhukov; Elena N. Khurs; Radii M. Khomutov
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 69 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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π SIMILAR VOLUMES
## Abstract This article describes the radiosynthesis of ^11^Cβlabelled Sβadenosylmethionine by an enzymatic process. This methyl donor was prepared by condensation of Lβ(methylβ^11^C) methionine with ATP. The synthesis and purification could be carried out in 20 minutes with a final yield of 80 %.
S-Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [ 11,12-2H]chenodeoxy