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Benign recurrent intrahepatic cholestasis: Failure of S-adenosylmethionine therapy

✍ Scribed by Harold O. Conn; C. N. Ghent

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 272 KB
Volume: 12
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840120227

No coin nor oath required. For personal study only.

✦ Synopsis

S-Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [ 11,12-2H]chenodeoxycholic acid and [24-'3Clcholic acid were determined before and after treatment with S-adenosylmethionine. S-Adenoqlmethionine did not ameliorate symptoms or biochemical parameters of cholestasis but reduced bile acid clearances in 3 of 4 subjects. Transaminase levels in both subjects of one kindred rose during treatment. These limited, preliminary observations suggest that S-adenosylmethionine may be ineffective in the therapy of benign recurrent intrahepatic cholestasis and may be hepatotoxic in some patients.

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