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Stabilization of DNA structure by histones against thermal denaturation

✍ Scribed by H. P. Hahn

Book ID
112700408
Publisher
Springer
Year
1965
Tongue
English
Weight
242 KB
Volume
21
Category
Article
ISSN
1420-682X

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✍ Michael H. Hecht; Julian M. Sturtevant; Robert T. Sauer πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 332 KB

Oligonucleotide-directed mutagenesis has been used to replace alpha-helical glycines in the N-terminal domain of lambda repressor with alanines. Since alanine is a significantly better helix-forming residue than glycine, these changes were predicted to have a stabilizing effect. We show that the Gly