## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysis, point mutations in the DNA mismatch repair genes __MSH2__ and __MLH1__ have been detected in up to 64% of patients suspected of H
Stability of BAT26 in tumours of hereditary nonpolyposis colorectal cancer patients with MSH2 intragenic deletion
β Scribed by Pastrello, Chiara; Baglioni, Silvana; Tibiletti, Maria Grazia; Papi, Laura; Fornasarig, Mara; Morabito, Alberto; Agostini, Marco; Genuardi, Maurizio; Viel, Alessandra
- Book ID
- 110026521
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 173 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1018-4813
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Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred
## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal disorder caused by mutations in DNA mismatch repair (MMR) genes. Tumors of the HNPCCβspectrum are associated with microsatellite instability (MSI) and loss of MMR protein expression. Lymphomas are not considered to be HNP