Aspirin rapidly hydrolyzes in various aqueous, organic, and biological media. The purpose of this investigation was to study the decomposition of aspirin in the media that comes in contact with it during analysis in biological fluids for pharmacokinetic studies. These media included water, water-pol
Stability of aspirin in different media
โ Scribed by Shamsul K. Bakar; Sarfaraz Niazi
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 384 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3549
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It has been shown that the degradation of aspirin in mixtures may be monitored by thermal analytical techniques. The methodology employed differential scanning calorimetry and thermal gravimetric analysis by standard techniques providing simple and rapid analysis for screening the stability of aspir
Temperature stability studies were conducted on 0.36 M (6.5% w/v) aspirin solutions including either 0.02 M L-methionine or 0.02 M histidine in propylene glycol. Aspirin was determined spectrophotofluorometrically as salicylic acid content at 412 nm. A 0.36 M aspirin in polyethylene glycol 400 solut