Peptide stability in drug development: A comparison of peptide reactivity in different biological media
✍ Scribed by Michael F. Powell; Howard Grey; Federico Gaeta; Alex Sette; Sonia Colón
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 549 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0022-3549
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A peptide fragment corresponding to the third helix of Staphylococcus Aureus protein A, domain B, was chosen to study the effect of the main-chain direction upon secondary structure formation and stability, applying the retro-enantio concept. For this purpose, two peptides consisting of the native (
## Synopsis An estimation of the thermodynamic effects of a charged random coil, which is attached either to the Nor C-terminus of polyalanine, upon a-helix stability is attempted. A temperature induced helix-coil transition of Ala,Lys,Phe and Lys,Ala,Phe was studied under various conditions of sa