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Stability of aspirin in solid mixtures

โœ Scribed by David J. Ager; Kenneth S. Alexander; Asif S. Bhatti; John S. Blackburn; David Dollimore; Timothy S. Koogan; Keith A. Mooseman; George M. Muhvic; Belinda Sims; Victoria J. Webb

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
473 KB
Volume
75
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

It has been shown that the degradation of aspirin in mixtures may be monitored by thermal analytical techniques. The methodology employed differential scanning calorimetry and thermal gravimetric analysis by standard techniques providing simple and rapid analysis for screening the stability of aspirin in mixtures. The degradation was found to depend on the nature of the additive but, in particular, the presence of acidic or basic groups within its structure.

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Aspirin rapidly hydrolyzes in various aqueous, organic, and biological media. The purpose of this investigation was to study the decomposition of aspirin in the media that comes in contact with it during analysis in biological fluids for pharmacokinetic studies. These media included water, water-pol