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Amino acid effect on aspirin stability in propylene glycol

✍ Scribed by Prem K. Narang; James K. Lim

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 389 KB
Volume: 68
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600680536

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✦ Synopsis

Temperature stability studies were conducted on 0.36 M (6.5% w/v) aspirin solutions including either 0.02 M L-methionine or 0.02 M histidine in propylene glycol. Aspirin was determined spectrophotofluorometrically as salicylic acid content at 412 nm. A 0.36 M aspirin in polyethylene glycol 400 solution was studied concurrently. Aspirin degradation rate constants, k, obtained from semilogarithmic plots of percent drug remaining uersus time at 30-70 f 0.5' were used for preparing Arrhenius plots. Good correlation was seen between predicted aspirin stability and experimental k2.p-values. L-Methionine and histidine markedly reduced aspirin stability.

Keyphrases Aspirin-stability in propylene glycol, effect of L-me-

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