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Effect of water vapor pressure on moisture sorption and the stability of aspirin and ascorbic acid in tablet matrices

✍ Scribed by Sumtung Lee; H. George Dekay; Gilbert S. Banker

Publisher
John Wiley and Sons
Year
1965
Tongue
English
Weight
535 KB
Volume
54
Category
Article
ISSN
0022-3549

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✦ Synopsis

A study of the effects of temperature and humidity conditions on the stability of aspirin and ascorbic acid in various solid matrices was conducted. Among the diluents studied, cellulose and calcium sulfate were found to confer maximum stability on formulations of aspirin and ascorbic acid. The tablet matrices were found to sorb water according to Van der Waal's adsorption mechanisms. The stability of the drugs was found to vary according to an interrelationship between tablet hardness and the moisture sorption of the compressed matrix. Two parameters, ( a ) the stability ratio or the ratio of the residual drug concentration of the tableted drugs in closed containers to the residual drug concentration of exposed tablet samples and (b) the moisture uptake of the dosage units in closed containers, were established to evaluate the packaging methods. Cello hane or aluminum foil strip packaging single dosage containers were found to ! e superior to wellclosed glass or plastic containers as moisture barriers under the intermediate-tohigh water vapor pressure conditions studied.

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