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Sporadic and Familial Medullary Thyroid Carcinoma: State of the Art

✍ Scribed by Moo-Young, Tricia A.; Traugott, Amber L.; Moley, Jeffrey F.

Book ID
121747082
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
624 KB
Volume
89
Category
Article
ISSN
0039-6109

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Medullary thyroid carcinoma (MTC) occurs sporadically or as part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. In MEN 2A, germline missense mutations are found in one of five cysteine codons within exons 10 and I I in the extracellular domain of the RET protooncogene. I