Diagnosis and therapy of sporadic and familial medullary thyroid carcinoma
β Scribed by Oliver Gimm; Thomas Sutter; Henning Dralle
- Publisher
- Springer-Verlag
- Year
- 2001
- Tongue
- English
- Weight
- 110 KB
- Volume
- 127
- Category
- Article
- ISSN
- 1432-1335
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π SIMILAR VOLUMES
Medullary thyroid carcinoma (MTC) occurs sporadically or as part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. In MEN 2A, germline missense mutations are found in one of five cysteine codons within exons 10 and I I in the extracellular domain of the RET protooncogene. I
The cytomorphologic features in fine-needle aspiration (FNA) biopsies from 91 histologiacally verified medullary carcinomas of the thyroid (MCT) were investigated. FNA was able to diagnose neoplasms with indications of surgical removal in 98.9% of cases and moreover, was accurate in specific tumor t