Medullary carcinoma of thyroid. Biologic behavior of the sporadic and familial neoplasm
β Scribed by Kennichi Kakudo; J. Aidan Carney; Glen W. Sizemore
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 347 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0008-543X
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The presence and distribution of S-100-immunoreactive sustentacular cells were investigated by immunohistochemistry in 67 medullary thyroid carcinomas (MTCs). The familial or sporadic status of the tumours was assessed by clinical data and confirmed by the identification of RET germline mutations us
## BACKGROUND. Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from parafollicular cells. At present, surgery is the most important treatment for MTC. ## METHODS. We describe the current approaches of MTC treatment (surgery, chemotherapy, radiation therapy, and biologic ther
## Background: The results and consequences of genetic testing in a family with familial medullary thyroid carcinoma (fmtc) are described. ## Methods: In the screening of relatives, serum calcitonin is replaced by ret mutation analysis that was performed in families suspected of hereditary medull