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Prevalence and Clinical Spectrum of Nonsecretory Medullary Thyroid Carcinoma in a Series of 839 Patients with Sporadic Medullary Thyroid Carcinoma

✍ Scribed by Frank-Raue, Karin; Machens, Andreas; Leidig-Bruckner, Gudrun; Rondot, Susanne; Haag, Christine; Schulze, Egbert; Lorenz, Angela; Kreissl, Michael C.; Dralle, Henning; Raue, Friedhelm; Schmid, Kurt W.

Book ID
121470719
Publisher
Mary Ann Liebert
Year
2013
Tongue
English
Weight
161 KB
Volume
23
Category
Article
ISSN
1050-7256

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Medullary thyroid carcinoma (MTC) occurs sporadically or as part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. In MEN 2A, germline missense mutations are found in one of five cysteine codons within exons 10 and I I in the extracellular domain of the RET protooncogene. I