Spontaneous racemization of chlorthalidone: kinetics and activation parameters
โ Scribed by Gregory Severin
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 489 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0899-0042
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๐ SIMILAR VOLUMES
Ethyl formate undergoes spontaneous autocatalytic hydrolysis via water catalyzed (neutral), as well as hydrogen-ion catalyzed mechanisms. The activation parameters for the neutral reaction are โฌH โก ฯญ 91 ฯฎ 8 kJ/mol and โฌS โก ฯญ ฯช48 ฯฎ 8 J K ฯช1 /mol. This result is in contrast to the values reported in t
The kinetics and mechanism of racemization of allantoin have been examined; racemization proceeds via two independent pathways that can be separately monitored. One pathway involves proton exchange at C5 with solvent. The other pathway occurs via intramolecular attack of N8 on C4 to form a symmetric