Racemization of chlorthalidone in the presence of liposomes
✍ Scribed by Dr. Erich Lamparter; Gottfried Blaschke; Jürgen Schlüter
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 352 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0899-0042
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## Abstract Solution‐phase racemization drives the evolution of single chirality in the solid phase by the “chiral amnesia” process first described by Viedma. The current investigations lay the basis for a better understanding of the mechanism of the solid‐phase deracemization by uncoupling the che
## Abstract A single oral dose of the diuretic chlorthalidone (100 or 200 mg) was given to six cholecystectomized patients with T‐tube drainage of the common bile duct, and the 24 h bile and urine were collected during 3–7 days. Urinary recovery of chlorthalidone was 23–27 per cent of the dose, whi
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