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Spongistatin synthetic studies. 2. Assembly of the C(18–28) spiroketal

✍ Scribed by Amos B. Smith III; Linghang Zhuang; Christopher S. Brook; Qiyan Lin; William H. Moser; Robert E. Lee Trout; Armen M. Boldi

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
229 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The C(18-28) CD-ring spiroketal subunit of the spongistatins, marine polyether macrolides with unprecedented antitumor activity, has been generated via a highly convergent and completely stereocontrolled sequence. Key operations include a one-flask dithiane bisalkylation and a metal-assisted spiroketal equilibration.

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