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Spongistatin synthetic studies. 3. Construction of the C(1–17) spiroketal

✍ Scribed by Amos B. Smith III; Quyan Lin; Kiyoshi Nakayama; Armen M. Boldi; Christopher S. Brook; Mark D. McBriar; William H. Moser; Masao Sobukawa; Linghang Zhuang

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
218 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A convergent synthesis of the C(1-17) AB-ring subunit of the spongistatins, exceedingly scarce and highly ant]mitotic polyether macrolides, has been achieved via a one-flask dithiane bisalkylation, stereocontrolled spiroketalization, and Julia sulfone coupling/methylenation. © ]997 Elsevier Science Ltd.

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