Specificity of antibodies to type II collagen in rheumatoid arthritis
β Scribed by Kuniaki Terato; Yasunori Shimozuru; Kou Katayama; Yoshiharu Takemitsu; Izumi Yamashita; Makoto Miyatsu; Katsuyuki Fujii; Mitsusada Sagara; Shiegeto Kobayashi; Makoto Goto; Kusuki Nishioka; Nobuyuki Miyasaka; Yutaka Nagai
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 793 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0004-3591
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Objective. To investigate the production of type I1 collagen (CII) antibodies in the synovial fluid (SF) of rheumatoid arthritis (RA) patients, and to examine the HLA dependence of this local production. Methods. The ELISPOT method was used for enumerating anti-CII-reactive cells. Serologic tissue
Production of antibodies to IgG and to type I and type I1 collagen (CI and CII) was analyzed by enzymelinked immunospot assay in patients with rheumatoid arthritis (RA) and patients with other inflammatory or degenerative joint diseases. Anti-CII-secreting cells, generally in high numbers, were foun