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Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis

✍ Scribed by Andrej Tarkowski; Hans Carlsten; Peter Herberts; Lars Klareskog; William J. Koopman

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
539 KB
Volume
32
Category
Article
ISSN
0004-3591

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✦ Synopsis

Production of antibodies to IgG and to type I and type I1 collagen (CI and CII) was analyzed by enzymelinked immunospot assay in patients with rheumatoid arthritis (RA) and patients with other inflammatory or degenerative joint diseases. Anti-CII-secreting cells, generally in high numbers, were found among mononuclear cells eluted from inflamed synovial tissue in 12 of 13 patients with seropositive RA and 9 of 14 patients with seronegative RA or with undetermined serum rheumatoid factor levels. In contrast, no anti-CII-producing B cells were present among synoviocytes from 4 patients with other joint diseases. In none of 7 RA sera did we find significant levels of anti-CII. Synovial B cells From the Departments of Clinical Immunology, Rheuma-

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