✦ LIBER ✦

Ia+ T Cells in Synovial Fluid And Tissues of Patients with Rheumatoid Arthritis

✍ Scribed by Gerd R. Burmester; David T. Y. Yu; Anne-Marie Irani; Henry G. Kunkel; Robert J. Winchester

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 607 KB
Volume: 24
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780241106

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Markedly elevated levels of T cells expressing Ia antigens were found in the synovial membranes and synovial fluids of patients with rheumatoid arthritis. The primary increase in expression of the la antigens was on the OKT 8+ (suppressor/cytotoxic) T cell subset. In addition, the total percentage of OKT 8+ T cells in intraarticular sites was usually greater than levels in peripheral blood. Small numbers of OKT 4+ (helper/inducer) cells bearing la antigens were also identified. The characteristic increase in the Ia+ T cells in peripheral blood was not encountered in most patients treated with D‐penicillamine.

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