Antibodies to type II collagen in early rheumatoid arthritis. Correlation with disease progression
β Scribed by Andrew D. Cook; Merrill J. Rowley; Ian R. Mackay; Andrew Gough; Paul Emery
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 767 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0004-3591
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π SIMILAR VOLUMES
Objective. To investigate the production of type I1 collagen (CII) antibodies in the synovial fluid (SF) of rheumatoid arthritis (RA) patients, and to examine the HLA dependence of this local production. Methods. The ELISPOT method was used for enumerating anti-CII-reactive cells. Serologic tissue
Production of antibodies to IgG and to type I and type I1 collagen (CI and CII) was analyzed by enzymelinked immunospot assay in patients with rheumatoid arthritis (RA) and patients with other inflammatory or degenerative joint diseases. Anti-CII-secreting cells, generally in high numbers, were foun