Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells – how diverse signals regulate suppression
✍ Scribed by Bin Li; Mark I. Greene
- Book ID
- 108782262
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 228 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0019-2805
No coin nor oath required. For personal study only.
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## Abstract Interleukin‐2 (IL‐2) treatment is currently used to enhance T cell‐mediated immune responses against tumors or in viral infections. At the same time, IL‐2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that IL‐2 is a
## Abstract Regulatory T cells (Treg cells) have been well documented to have a crucial physiological role in preventing the development of autoimmune diseases and keeping self‐tolerance. Foxp3, a recently identified member of the forkhead transcription factors, serves as a master regulator for the