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Sp1 Sites Mediate Activation of the Plasminogen Activator Inhibitor-1 Promoter by Glucose in Vascular Smooth Muscle Cells

✍ Scribed by Chen, Y.-Q.

Book ID
118028120
Publisher
The American Society for Biochemistry and Molecular Biology
Year
1998
Tongue
English
Weight
270 KB
Volume
273
Category
Article
ISSN
0021-9258

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## Abstract Increased expression of plasminogen activator inhibitor type 1 (PAI‐1) is associated with decreased apoptosis of neoplastic cells. We sought to determine whether PAI‐1 alters apoptosis in vascular smooth muscle cells (VSMC) and, if so, by what mechanisms. A twofold increase in the expre