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Increased expression of plasminogen activator inhibitor type 1 promotes proliferation of vascular smooth muscle cells

✍ Scribed by Yabing Chen; David Schneider; Burton Sobel

Book ID
116984088
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
60 KB
Volume
40
Category
Article
ISSN
0022-2828

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## Abstract Increased expression of plasminogen activator inhibitor type 1 (PAI‐1) is associated with decreased apoptosis of neoplastic cells. We sought to determine whether PAI‐1 alters apoptosis in vascular smooth muscle cells (VSMC) and, if so, by what mechanisms. A twofold increase in the expre