P53 Gemfibrozil inhibits specifically the expression of plasminogen activator inhibitor type 1 in adult arterial smooth muscle cells
- Book ID
- 117439922
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 128 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0268-9499
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## Abstract Increased expression of plasminogen activator inhibitor type 1 (PAIβ1) is associated with decreased apoptosis of neoplastic cells. We sought to determine whether PAIβ1 alters apoptosis in vascular smooth muscle cells (VSMC) and, if so, by what mechanisms. A twofold increase in the expre
## Abstract Transforming growth factorβΞ²1 (TGFβΞ²1) stimulates expression of plasminogen activator inhibitor typeβ1 (PAIβ1), a serine protease inhibitor (__SERPIN__) important in the control of stromal barrier proteolysis and cellβtoβmatrix adhesion. Pharmacologic agents that target MEK (PD98059, U0