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Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension

✍ Scribed by Fotini M. Kouri; Markus A. Queisser; Melanie Königshoff; Izabella Chrobak; Klaus T. Preissner; Werner Seeger; Oliver Eickelberg

Book ID
116307551
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
841 KB
Volume
40
Category
Article
ISSN
1357-2725

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## Abstract Increased expression of plasminogen activator inhibitor type 1 (PAI‐1) is associated with decreased apoptosis of neoplastic cells. We sought to determine whether PAI‐1 alters apoptosis in vascular smooth muscle cells (VSMC) and, if so, by what mechanisms. A twofold increase in the expre