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Enhancement by Homocysteine of Plasminogen Activator Inhibitor-1 Gene Expression and Secretion from Vascular Endothelial and Smooth Muscle Cells

โœ Scribed by Sanae Midorikawa; Hironobu Sanada; Sigeatsu Hashimoto; Tsuyoshi Watanabe


Book ID
115585839
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
113 KB
Volume
272
Category
Article
ISSN
0006-291X

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## Abstract Increased expression of plasminogen activator inhibitor type 1 (PAIโ€1) is associated with decreased apoptosis of neoplastic cells. We sought to determine whether PAIโ€1 alters apoptosis in vascular smooth muscle cells (VSMC) and, if so, by what mechanisms. A twofold increase in the expre