Inhibition of plasminogen activator inhibitor-1 expression in vascular smooth muscle cells by protoporphyrins through a heme oxygenase-independent mechanism

Inhibition of apoptosis and caspase-3 in

Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1

✍ Yabing Chen; Robert J. Kelm Jr.; Ralph C. Budd; Burton E. Sobel; David J. Schnei 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 253 KB 👁 1 views

## Abstract Increased expression of plasminogen activator inhibitor type 1 (PAI‐1) is associated with decreased apoptosis of neoplastic cells. We sought to determine whether PAI‐1 alters apoptosis in vascular smooth muscle cells (VSMC) and, if so, by what mechanisms. A twofold increase in the expre