Some β-hydroxy-sulphides as leukotriene D4 antagonists
✍ Scribed by S.R. Baker; J.R. Boot; W.J. Ross; A. Todd
- Book ID
- 119049793
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 43 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0090-6980
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📜 SIMILAR VOLUMES
The stereocontrolled synthesis of conformationally restricted LTD4 analogs 2a. b is described. Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5 and cis-epoxide 9. Stereocontrolled elaboration of each epoxide to final product involves stereoselective Wittig olefination to Z-olefins 6
The enantiomeric pair of conformationally-restricted nor-LTD4 analogs s and 11 have been synthesized stereoselectively from (g)-2-cyclohexen-l-01. Due to our continuing interest in the stereoselective syntheses of conformationallyrestricted LTDl analogsr, we were attracted by recent reports' that 2-