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Phenylephrine derivatives as leukotriene D4 antagonists

โœ Scribed by Musser, John H.; Kubrak, Dennis M.; Bender, Reinhold H. W.; Kreft, Anthony F.; Nielsen, Susan T.; Lefer, Allan M.; Chang, Joseph; Lewis, Alan J.; Hand, James M.


Book ID
125417945
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
844 KB
Volume
30
Category
Article
ISSN
0022-2623

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Conformationally restricted leukotriene
โœ Jeffrey S. Sabol; Philip M. Weintraub; Thomas H. Gieske; Robert J. Cregge ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 385 KB

The stereocontrolled synthesis of conformationally restricted LTD4 analogs 2a. b is described. Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5 and cis-epoxide 9. Stereocontrolled elaboration of each epoxide to final product involves stereoselective Wittig olefination to Z-olefins 6