✦ LIBER ✦

Leukotriene receptor antagonists. 4. Synthesis and leukotriene D4/E4 receptor antagonist activity of 4-(alkyl)acetophenone derivatives

✍ Scribed by Gapinski, D. Mark; Roman, Carlos R.; Rinkema, Lynn E.; Fleisch, Jerome H.

Book ID: 120387498
Publisher: American Chemical Society
Year: 1988
Tongue: English
Weight: 600 KB
Volume: 31
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00396a027

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Novel Phthalimide Derivatives, Designed

Novel Phthalimide Derivatives, Designed as Leukotriene D4 Receptor Antagonists.

✍ Lidia M. Lima; Fernanda C. F. de Brito; Simone D. de Souza; Ana L. P. Miranda; C 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

o-Phenylphenols: potent and orally activ

o-Phenylphenols: potent and orally active leukotriene B4 receptor antagonists

✍ Sofia, Michael J.; Floreancig, Paul; Bach, Nicholas J.; Baker, S. Richard; Cocke 📂 Article 📅 1993 🏛 American Chemical Society 🌐 English ⚖ 527 KB

Synthesis and Leukotriene D4/E4 Receptor

Synthesis and Leukotriene D4/E4 Receptor Antagonist Activity of LY223468 and LY281761, “Carba” Analogues of LY171883

✍ D. MARK GAPINSKI; CARLOS R. ROMAN; LYNN E. RINKEMA; JEROME H. FLEISCH 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 104 KB

Conformationally restricted leukotriene

Conformationally restricted leukotriene antagonists. Synthesis of chiral 4-hydroxy-4-alkylcyclohexanecarboxylic acids as leukotriene D4 analogs

✍ Cregge, Robert J.; Lentz, Nelsen L.; Sabol, Jeffrey S. 📂 Article 📅 1991 🏛 American Chemical Society 🌐 English ⚖ 783 KB

Conformationally restricted leukotriene

Conformationally restricted leukotriene antagonists. Stereoselective synthesis of some leukotriene D4 analogs

✍ Jeffrey S. Sabol; Philip M. Weintraub; Thomas H. Gieske; Robert J. Cregge 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 385 KB

The stereocontrolled synthesis of conformationally restricted LTD4 analogs 2a. b is described. Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5 and cis-epoxide 9. Stereocontrolled elaboration of each epoxide to final product involves stereoselective Wittig olefination to Z-olefins 6

Immunosuppressive Effect of Leukotriene

Immunosuppressive Effect of Leukotriene B4 Receptor Antagonist in Vitro

✍ Hiroaki Morita; Kazuyoshi Takeda; Hideo Yagita; Ko Okumura 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 102 KB