Somatostatinergic phenotype markers in the human neuroblastoma cell-line LA-N-2
✍ Scribed by Lars Nilsson; Lena Bergström; Gabrielle Meyersson; Sven Påhlman; Bengt Winblad; Ronnie Folkesson
- Book ID
- 115931297
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 586 KB
- Volume
- 372
- Category
- Article
- ISSN
- 0014-5793
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## Abstract The presence of 10^−5^ M retinoec acid (RA) in the culture medium of LA‐N‐1, a catecholamonergic cell line, and LA‐N‐2, a cholinergic cell line, enhanced their morphological differentiation. Tyrosine hydroxylase (TH) activity of the LA‐N‐1 cell was increased in the RA‐treated cells comp
Whilst many human neuroblastorna cell lines have been studied to see if they are capable of taking up mlBG, few appear to have this ability. This contrasts markedly to the situation in vivo, where uptake has been demonstrated in the majority of tumours investigated. Here we report on the human neuro