The metabolic fate of [3H-methyl]choline in cultured human neuroblastoma cell lines, LA-N-1 and LA-N-2

Enzymatic activites during differentiati

Enzymatic activites during differentiation of the human neuroblastoma cells, LA-N-1 and LA-N-2

✍ I. N. Singh; G. Sorrentino; D. G. McCartney; R. Massarelli; Professor J. N. Kanf 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 824 KB

## Abstract The presence of 10^−5^ M retinoec acid (RA) in the culture medium of LA‐N‐1, a catecholamonergic cell line, and LA‐N‐2, a cholinergic cell line, enhanced their morphological differentiation. Tyrosine hydroxylase (TH) activity of the LA‐N‐1 cell was increased in the RA‐treated cells comp