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Somatic pairing of centromeres and short arms of chromosome 15 in the hematopoietic and lymphoid system

✍ Scribed by Jerry P. Lewis; Hans J. Tanke; Anton K. Raap; Geoffrey C. Beverstock; Hanneke C. Kluin-Nelemans

Publisher: Springer
Year: 1993
Tongue: English
Weight: 914 KB
Volume: 92
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00420942

No coin nor oath required. For personal study only.

✦ Synopsis

Normal human bone marrow and peripheral blood leukocytes as well as malignant cells from a variety of leukemias and lymphomas, demonstrate somatic pairing of centromeres and p arms of chromosome 15 during interphase. This phenomenon, effected by sequences on the p arm and requiring the intranuclear transport of spatial domains for at least one of the homologs, was not seen in amniotic fluid cells, uterine cervical tissue or in tissue fibroblasts. These studies contribute to the recent evidence of somatic pairing of homologous chromosomes in man and provide support for mobile chromosomal domains in interphase. It appears that sequences on the p arm of chromosome 15, possibly the nucleolar organizing genes, are uniquely important in the maturation of benign and malignant cells of hemato-lymphopoietic origin.

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