✦ LIBER ✦

Loss of alleles on chromosome 18 and on the short arm of chromosome 17 in polyploid colorectal carcinomas

✍ Scribed by J.-Ph. Monpezat; O. Delattre; A Bernard; D. Grunwald; Y. Remvikos; M. Muleris; R. J. Salmon; G. Frelat; B. Dutrillaux; G. Thomas

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 582 KB
Volume: 41
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910410315

No coin nor oath required. For personal study only.

✦ Synopsis

The zygosity of 19 colorectal carcinomas (either near-diploid or polyploid) from patients known to be heterozygous for RFLPs located on chromosome 18 or on the short arm of chromosome 17 has been examined. In most cases, at least one allele was significantly under-represented. The reason for the absence of complete loss of heterozygosity was investigated for 5 polyploid tumors. It was shown that the diploid component which, in these tumors, is essentially composed of non-neoplastic cells, remains heterozygous as the polyploid component invariably loses heterozygosity. The results strongly suggest that many colorectal carcinomas originate from a single cell which had lost at least part of either chromosome 18 or of one short arm of chromosome 17. or both.

'To whom reprint requests should be addressed.

📜 SIMILAR VOLUMES

Allelic loss on the short arm of chromos

Allelic loss on the short arm of chromosome 11 in non-small-cell lung cancer

✍ Christian U. Ludwig; Gaby Raefle; Peter Dalquen; Peter Stulz; Rolf Stahel; Jean- 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 505 KB

Forty-eight samples of primary non-small-cell lung cancer (NSCLC) and normal tissue from the same patients were analyzed for allelic deletions on chromosome I I p. Five polymorphic loci were assessed to determine the incidence of I Ip sequence deletions and to define hot-spots of deletions. Informat

Loss of heterozygosity on chromosome arm

Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma

✍ Li-Fu Hu; Gudny Eiriksdottir; Tatyana Lebedeva; Irina Kholodniouk; Andrei Alimov 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 720 KB

We have examined I 7 primary undifferentiated nasopharyngeal carcinoma biopsies for allelic loss on 3p, comparing the findings in tumors with those in normal lymphocyte D N A from the same patients. Ten polymorphic microsatellite markers were used between 3p I 3 and 3p26. Allelic IOU was observed in

p53 MUTATION, ALLELE LOSS ON CHROMOSOME

p53 MUTATION, ALLELE LOSS ON CHROMOSOME 17p, AND DNA CONTENT IN OVARIAN CARCINOMA

✍ McMANUS, D. T.; MURPHY, M.; ARTHUR, K.; HAMILTON, P. W.; RUSSELL, S. E. H.; TONE 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 569 KB

The aim of this investigation was to explore the relationships between pS3 mutation, DNA aneuploidy, 17p deletions, and clinical stage in ovarian cancer. Nuclear suspensions were obtained by tissue disaggregation, stained with propidium iodide, and analysed on a Coulter EPICS Elite flow cytometer. D

High frequency of allelic deletion on ch

High frequency of allelic deletion on chromosome 17p in advanced colorectal cancer

✍ Kyaw Khine; Duncan R. Smith; Hak-Su Goh 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 962 KB

Background. Colorectal cancers often show allelic loss of chromosomes 5q and 17p, regions where the tumor suppressor genes p53 and adenomatous polyposis coli are known to reside. Currently, the inactivation of tumor suppressor genes and the activation of oncogenes are considered major events involve

Frequency and extent of allelic loss in

Frequency and extent of allelic loss in the short arm of chromosome 3 in nonsmall-cell lung cancer

✍ Dr. Pamela Rabbitts; Jenny Douglas; Maria Daly; Vasi Sundaresan; Bernard Fox; Ph 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 734 KB

DNA was prepared from tumour and normal tissue from 48 patients representing all common histological types of nonsmall-cell lung cancer. Using eight DNA probes, which detect nine restriction enzyme fragment length polymorphisms (RFLP) on chromosome 3, we established that among the 44 informative pat

Loss of heterozygosity on chromosomes 10

Loss of heterozygosity on chromosomes 10 and 17 in clinically localized prostate carcinoma

✍ Ittmann, Michael M. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 665 KB

Loss of heterozygosity (LOH) at chromosomal loci has been associated with the presence of tumor suppressor genes at the deleted loci. Twenty-six clinically localized, Stage B prostate carcinomas were analyzed for LOH on chromosomes 10 and 17 using microsatellite markers. Two of 26 carcinomas showed