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Loss of heterozygosity on chromosomes 10 and 17 in clinically localized prostate carcinoma

✍ Scribed by Ittmann, Michael M.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 665 KB
Volume: 28
Category: Article
ISSN: 0270-4137
DOI: 10.1002/(sici)1097-0045(199605)28:5<275::aid-pros1>3.0.co;2-b

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✦ Synopsis

Loss of heterozygosity (LOH) at chromosomal loci has been associated with the presence of tumor suppressor genes at the deleted loci. Twenty-six clinically localized, Stage B prostate carcinomas were analyzed for LOH on chromosomes 10 and 17 using microsatellite markers. Two of 26 carcinomas showed LOH on 17p while one showed LOH on 17q. Chromosome 10 showed a complex pattern of LOH with monosomy (1 case), LOH on lop (1 case), proximal 1Oq (1 case) and distal 1Oq (2 cases). Overall 29% of informative cases showed LOH on chromosome 10. These results are consistent with the presence of a tumor supressor for prostate cancer on 17p and multiple tumor supppressor genes on chromosome 10.

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