✦ LIBER ✦

BRCA1 gene mutation and loss of heterozygosity on chromosome 17q21 in primary prostate cancer

✍ Scribed by Toyoaki Uchida; Chunxi Wang; Takefumi Sato; Jiangping Gao; Rikiya Takashima; Akira Irie; Makoto Ohori; Ken Koshiba

Publisher: John Wiley and Sons
Year: 1999
Tongue: French
Weight: 113 KB
Volume: 84
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19990219)84:1<19::aid-ijc4>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

The tumor suppressor gene BRCA1 on chromosome 17q21 has been characterized and shown to be mutated in patients with familial breast and ovarian cancer. Several studies examined the relatives of women with breast cancer and noted an association with ovarian and prostate cancer. This study investigated 24 human prostate cancer specimens for BRCA1 gene mutations and loss of heterozygosity (LOH) on chromosome 17q21 assessed by the polymerase chain reaction. LOH was identified using 7 highly polymorphic tandem repeat markers on chromosome 17q21, in addition to an analysis of the whole coding region of the BRCA1 gene. Four of the 24 prostate cancer specimens showed LOH at one or more loci, all of which were histologically poorly differentiated (4 of 11) and stage D (4 of 15). One of the 24 cases showed a germ-line mutation of the BRCA1 gene, and a sister of this patient died of ovarian cancer. It appears that the BRCA1 gene is not frequently involved in the development of primary prostate cancer.

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