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Somatic p16INK4a loss accelerates melanomagenesis

✍ Scribed by Sharpless, N E; Monahan, K B; Rozenberg, G I; Krishnamurthy, J; Johnson, S M; Liu, W; Bradford, M K; Horner, J; DePinho, R A


Book ID
109972490
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
651 KB
Volume
29
Category
Article
ISSN
0950-9232

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The cell cycle is composed of a series of steps that can be negatively or positively regulated by various factors. A group of low-molecular-weight proteins have recently been identified that specifically inhibit the function of cyclin-dependent kinases in mammalian cells. Inactivation of the CDKNZA