## Abstract Primary effusion lymphoma (PEL) is a rare KSHV/HHV8‐associated high‐grade non‐Hodgkin's lymphoma (NHL) of B‐cell origin, characterized by serous effusions in body cavities. Most patients are HIV‐infected homosexual men with severe immunosuppression and other KSHV/HHV8‐associated disease
p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma
✍ Scribed by Platt, Georgina; Carbone, Antonino; Mittnacht, Sibylle
- Book ID
- 110066559
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 282 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Primary effusion lymphoma (PEL) is a rare lymphoma of B‐cell origin, developed in serous cavities. PEL tumor cells are latently infected with Kaposi sarcoma‐associated herpesvirus (KSHV) and in most cases co‐infected with Epstein‐Barr virus (EBV). In 15 primary PEL tumors including 10 E
## Abstract Kaposi's sarcoma‐associated herpesvirus (KSHV) is a gammaherpesvirus etiologically linked to primary effusion lymphoma (PEL), to a subset of multicentric Castleman's disease and to Kaposi's sarcoma (KS), the most common neoplasm associated with AIDS. Among KSHV‐infected individuals, the