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Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

✍ Scribed by Merajver, Sofia D.; Pham, Trinh M.; Caduff, Rosemarie F.; Chen, Martha; Poy, Ellen L.; Cooney, Kathleen A.; Weber, Barbara L.; Collins, Francis S.; Johnston, Carolyn; Frank, Thomas S.

Book ID
109915707
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
557 KB
Volume
9
Category
Article
ISSN
1061-4036

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We screened 81 ovarian tumours (30 BRCA1 associated, 18 BRCA2 associated, and 33 sporadic) for somatic TP53 mutations using both DNA analysis and immunostaining. TP53 mutations were significantly more frequent in tumours with mutations in BRCA1 (70% by immunostaining and 60% by DNA analysis) and BRC