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Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer

โœ Scribed by Khoo, Ui-Soon; Ozcelik, Hilmi; Cheung, Annie NY; Chow, Louis WC; Ngan, Hextan YS; Done, Susan J; Liang, A C T; Chan, Vivian WY; Au, Gordon KH; Ng, Wing-Fung


Book ID
110062262
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
233 KB
Volume
18
Category
Article
ISSN
0950-9232

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The cloning of the breast and ovarian cancer susceptibility gene, BRCA1, allows direct estimation of the proportion of these cancers in the general population which can be attributed to germline mutations in this gene. We have used a combination of SSCP, heteroduplex analysis, and chemical cleavage