A somatic BRCA1 mutation in an ovarian tumour
β Scribed by Hosking, Louise; Trowsdale, John; Nicolai, Hans; Solomon, Ellen; Foulkes, William; Stamp, Gordon; Signer, Esther; Jeffreys, Alec
- Book ID
- 109915694
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 271 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1061-4036
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We screened 81 ovarian tumours (30 BRCA1 associated, 18 BRCA2 associated, and 33 sporadic) for somatic TP53 mutations using both DNA analysis and immunostaining. TP53 mutations were significantly more frequent in tumours with mutations in BRCA1 (70% by immunostaining and 60% by DNA analysis) and BRC
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