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Somatic mutations and single nucleotide polymorphisms of base excision repair genes involved in the repair of 8-hydroxyguanine in damaged DNA

✍ Scribed by Kazuya Shinmura; Satoru Yamaguchi; Takayuki Saitoh; Takashi Kohno; Jun Yokota

Book ID: 117466873
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 129 KB
Volume: 166
Category: Article
ISSN: 0304-3835
DOI: 10.1016/s0304-3835(01)00435-9

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The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased fr