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Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA

✍ Scribed by Giese, Heidi; Dollé, Martijn ET; Hezel, Aram; van Steeg, Harry; Vijg, Jan

Book ID
110061856
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
172 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract Induction of the p21^WAF1^ protein (hereafter called p21) following genotoxic stress is known to inhibit proliferating cell nuclear antigen (PCNA)‐dependent DNA repair, downregulate apoptosis, and trigger a sustained growth‐arrested phenotype called accelerated senescence. Studies with