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Solventless Synthesis of N -Protected Amino Acids in a Ball Mill

✍ Scribed by Konnert, Laure; Gauliard, Anne; Lamaty, Frédéric; Martinez, Jean; Colacino, Evelina


Book ID
125975780
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
377 KB
Volume
1
Category
Article
ISSN
2168-0485

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## Abstract Esters can be prepared from __N__‐hydroxyphthalimide and __N__‐carbobenzoxy‐ or __N__‐phthaloyl‐amino acids using dicyclohexylcarbodi‐imide as condensing agent. The compounds are suitable for the stepwise synthesis of peptides without racemization. With methanol the __N__‐hydroxyphthali