Use of ethoxyacetylene for the synthesis of N-protected amino-acids
✍ Scribed by Banks, G. R.; Cohen, D.; Pattenden, G. E.; Thomas, J. A. G.
- Book ID
- 120976783
- Publisher
- The Royal Society of Chemistry
- Year
- 1967
- Tongue
- English
- Weight
- 300 KB
- Category
- Article
- ISSN
- 0022-4952
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📜 SIMILAR VOLUMES
## Abstract Esters can be prepared from __N__‐hydroxyphthalimide and __N__‐carbobenzoxy‐ or __N__‐phthaloyl‐amino acids using dicyclohexylcarbodi‐imide as condensing agent. The compounds are suitable for the stepwise synthesis of peptides without racemization. With methanol the __N__‐hydroxyphthali
Papain catalyzed synthesis of glyceryl esters of BOC(Z)-protected amino acids and peptides was performed at 40-50°C in a 50 molar excess of glycerol. Equilibrium was achieved in 6-7 h. The maximal yield of esters (50-70%) was obtained at 10% of water and pH 3.2-3.4. A lower water concentration resul